Standardizing Molecular Testing for 24/7 Operationss

For modern, high-volume Blood Sciences and multi-discipline core laboratories, managing complex molecular assays manually is operationally inefficient. The Cube Dx platform addresses this hurdle by providing a standardized, highly automated workflow that does not require continuous attention from highly specialized molecular biologists, making rapid critical-care diagnostics available 24/7.

The 4-Step Analytical Architecture

The entire testing process is consolidated into an integrated, routine timeline that minimizes hands-on time and limits laboratory contamination risks:

• 1. Sample Prep & Enrichment (GINA):

Automatically depletes human background cells and purifies enriched microbial DNA directly from whole blood or respiratory specimens

• 2. Amplification (PCR-Boxes):

Employs pre-packaged, ready-to-use pan-bacterial and pan-fungal amplification reagents formatted as single reactions in cleanroom-manufactured 0.2mL tubes.

• 3. Hybridisation (hybcell):

Utilizes the world's first cylindrical microarray cartridge. DNA oligonucleotide targets are immobilized along a unique, coated cylindrical surface, allowing amplified targets to bind under automated rotation.

• 4. Automated Analysis (hyborg Dx RED Platform):

The hyborg instrument handles the fluidics, imaging, evaluation, and processing steps completely automatically, delivering up to 24 multi-target tests per cycle.

Built-In Quality Assurance & Contamination Protections

Operating a high-sensitivity molecular assay inside a core blood lab requires strict safeguards against false- positive results caused by environmental carry-over:

• Uracil-DNA Glycosylase (UNG):

All ready-to-use PCR master-mixes incorporate active UNG carry-over protection to eliminate residual amplicon contamination automatically.

• Internal Process Control (IPC):

Every reaction includes a built-in IPC co-amplification target to explicitly validate the absolute extraction efficiency and confirm the accuracy of every negative screening result.

Laboratory System Integration (LIMS) & Maintenance

The hyborg Dx RED software suite is engineered to minimize labor overhead and administrative transcription errors in busy laboratories:

• Automated Report Generation:

Eliminates manual sizing calculations by generating clear, automated PDF diagnostic printouts.

• LIMS Connectivity:

Full compatibility with laboratory information management systems allows automated results transfer straight into patient records.

• Minimal Maintenance Design:

The sealed, automated internal fluidics.